Biochip Technology

The Biosensor Technology team designs and develops silicon based biochips to analyse liquid samples for various applications.

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Biosensor System Engineering

The Biosensor Technology team constructs and develops portable and user friendly systems for control and read-out of biosensors:

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Electrical Array Biochips

Highly sensitive multi parameter detection tool for food analysis, process control or point-of-care diagnostics.

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Continuous Enzyme Sensors

Amperometric sensors for continuous monitoring of glucose or lactate.

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On-Chip Liquid Chromatography

The On-Chip Liquid Chromatography enables detection of small molecules in miniaturized systems.

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Biosensor Technology

The biosensor technology team develops and produces silicon based microsystems for high sophisticated biosensors used in miniaturized and mobile analysis platforms. The research focus addresses especially the topic “microsystems for health”.

There are core competencies in the fields of position specific immobilisation of biomolecules, micro fluidics, assay development, electro chemistry and biosensor system integration. Special piezo nano dispenser and a biological laboratory of security level 2 are available for various application developments.

Electrical micro-electrode array based tests are a main research field of the department. Position-specific applications are realized by immobilization of biomolecules and highly sensitive, highly selective measurement methods such as the "redox cycling". These very robust sensor systems are useful for the simultaneous detection of a variety of analytes within one sample. In combination with micro-fluidic components and integrated electronics, these electrical microarrays represent the basis of rapid and cost-effective analysis systems. They can be used to identify and quantify DNA, RNA, proteins and haptens.

In a further field of activity biosensors for the continuous monitoring, e.g. of metabolites as glucose or lactate are developed. The monitoring and quantification of these substances is realized by enzymatic conversion and electrochemical detection.

These sensors are also used in combination with pH-measurement and -control in bioreactors. In the BMBF-funded project "Cell-free bioproduction" ISIT integrates microelectrodes on pore membranes and also in microreactor systems for example (www.zellfreie-bioproduktion.fraunhofer.de).

For a wider range of mobile analytics, ISIT develops microsystems based on a liquid chromatographic separation process. Various materials, process technologies and system integration technologies are investigated. The aim of this development is an integrated microsystem for detection of contaminants and residues for a sustainable environment, food and health management.